what is life

What Is Life?
Mind and Matter
Author Erwin Schrödinger
Language English
Genre(s) Popular science
Publisher Cambridge University Press
Publication date 1944
Pages 194
ISBN 0521427088
OCLC Number 24503223
Dewey Decimal 574/.01 20
LC Classification QH331 .S357 1992
What Is Life? is a non-fiction book on science for the lay reader written by physicist Erwin Schrödinger. One of the discoverers of the structure of DNA, Francis Crick, credited What Is Life? as a theoretical description, before the actual discovery of the structure of DNA (the existence of the molecule had been known since 1869, but its role in reproduction and its helical shape had not even been guessed at this time), of how genetic storage would work and a source for inspiration for the initial research.[1]

In the book, Schrödinger introduced the idea of an "aperiodic crystal" that contained genetic information in its configuration of covalent chemical bonds. In the 1950s, this idea stimulated enthusiasm for discovering the genetic molecule. In retrospect, it could be seen as having been a well-reasoned theoretical prediction of what biologists should have been looking for during their search for the genetic material.

Contents [hide]
1 Overview
2 Background
3 Content
4 See also
5 External links
6 References


[edit] Overview
Schrödinger’s 1944 book What Is Life? was based on a course of public lectures delivered under the auspices of the Dublin Institute for Advanced Studies at Trinity College, Dublin, in February 1943. The audience, of about 400, which did not dwindle throughout the lecture, was warned initially, according to Schrödinger, "that the subject-matter was a difficult one and that the lectures could not be termed popular, even though the physicist’s most dreaded weapon, mathematical deduction, would hardly be utilized."

Schrödinger states on page one, chapter one, that the entire lecture will focus on one important question, namely "how can the events in space and time which take place within the spatial boundary of a living organism be accounted for by physics and chemistry?’ He continues, ‘the preliminary answer which this little book will endeavor to expound and establish can be summarized as follows: the obvious inability of present-day physics and chemistry to account for such events is no reason at all for doubting that they can be accounted for by those scientists.’[2]

[edit] Background
The book is based on lectures delivered under the auspices of the Institute at Trinity College, Dublin, in February 1943 and published in 1944. At that time DNA was not yet accepted as the carrier of hereditary information, which only was the case after the Hershey-Chase experiment of 1952.

One of the most successful branches of physics at this time was statistical physics, to which also Albert Einstein had contributed by explaining Brownian motion, and quantum mechanics, a theory which is also very statistical in its nature. Schrödinger himself is one of the founding fathers of quantum mechanics.

Max Delbrück's thinking about the physical basis of life was an important influence on Schrödinger.[3]

[edit] Content
In chapter I Schrödinger explains that most physical laws on a large scale are due to chaos on a small scale. He calls this principle "order-from-disorder." As an example he mentions diffusion, which can be modeled as a highly ordered process, but which is caused by random movement of atoms or molecules. If the number of atoms is reduced, the behaviour of a system becomes more and more random. He states that life greatly depends on order and that a naive physicist may assume that the master code of a living organism has to consist of a large number of atoms.

In chapter II and III he summarizes what was known at this time about the hereditary mechanism. Most importantly, he elaborates the important role mutations play in evolution. He concludes that the carrier of hereditary information has to be both small in size and permanent in time, contradicting the naive physicist's expectation. This contradiction cannot be resolved by classical physics.

In chapter IV he presents molecules, which are indeed stable even if they consist of only a few atoms, as the solution. Even though molecules were known before, their stability could not be explained by classical physics, but is due to the discrete nature of quantum mechanics. Furthermore mutations are directly linked to quantum leaps.

He continues to explain, in chapter V, that true solids, which are also permanent, are crystals. The stability of molecules and crystals is due to the same principles and a molecule might be called "the germ of a solid." On the other hand an amorphous solid, without crystalline structure, should be regarded as a liquid with a very high viscosity. Schrödinger believes the heredity material to be a molecule, which unlike a crystal does not repeat itself. He calls this an aperiodic crystal. The aperiodic nature allows to encode an almost infinite number of possibilities with a small number of atoms. He finally compares this picture with the known facts and finds it in accordance with them.

In chapter VI Schrödinger states:

...living matter, while not eluding the "laws of physics" as established up to date, is likely to involve "other laws of physics" hitherto unknown, which however, once they have been revealed, will form just as integral a part of science as the former.
He knows that this statement is open to misconception and tries to clarify it. The main principle involved with "order-from-disorder" is the Second Law of Thermodynamics, according to which entropy only increases. Schrödinger explains that living matter evades the decay to thermodynamical equilibrium by feeding on negative entropy. Life is based on a different principle, "order-from-order."

In chapter VII Schrödinger maintains that "order-from-order" is not absolutely new to physics; in fact, it is even simpler and more plausible. But nature follows "order-from-disorder", with some exceptions as the movement of the celestial bodies and the behaviour of mechanical devices such as clocks. But even those are influenced by thermal and frictional forces. The degree to which a system functions mechanically or statistically depends on the temperature. If heated, a clock ceases to function, because it melts. Conversely, if the temperature approaches absolute zero, any system behaves more and more mechanically. Some systems approach this mechanical behaviour rather fast with room temperature already being practically equivalent to absolute zero.

Schrödinger concludes this chapter and the book with philosophical speculations on determinism, free will, and the mystery of human consciousness. He is sympathetic to the Hindu concept of Brahman, by which each individual's consciousness is only a manifestation of a unitary consciousness pervading the universe. In the final paragraph, he points out that what is meant by "I" is not the collection of experienced events but "namely the canvas upon which they are collected.". If a hypnotist succeeds in blotting out all earlier reminiscences, he writes, there would be no loss of personal existence - "Nor will there ever be." (He references The Perennial Philosophy by Aldous Huxley as a "beautiful book" leveling with the view he has taken in the last chapter.)

[edit] See also
James D. Watson
Maurice Wilkins
Max Delbrück
Gibbs free energy
Quantum Aspects of Life
[edit] External links
Österr. Zentralbibliothek für Physik Scan of the title and first part of the contents
What-Is-Life PDF of What Is Life?
The Book Page Text of What Is Life?
Josef Seifert
Lukas K. Buehler (2000-2007). "The physico-chemical basis of life". WhatIsLife.com. http://www.whatislife.com/about.html. Retrieved 2007-10-22.
(Italian) Critical interdisciplinary review of Schrödinger's "What Is life?"
Review by Julian F. Derry
Quantum Aspects of Life
Schroedinger's influence on biology
[edit] References
^ Julian F. Derry (2004). "Book Review: What Is Life? By Erwin Schrödinger". Human Nature Review. http://www.human-nature.com/nibbs/04/erwin.html. Retrieved 2007-07-15.
^ Margulis, Lynn. & Sagan, Dorion. (1995). What Is Life? (pg. 1). Berkeley: University of California Press.
^ Dronamraju KR (November 1999). "Erwin Schrödinger and the origins of molecular biology". Genetics 153 (3): 1071–6. PMID 10545442. PMC 1460808. http://www.genetics.org/cgi/content/full/153/3/1071#Delbrucks_model.
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